JBSNF-000088 (6-Methoxynicotinamide) Purity HPLC ≥99%
Is a cutting-edge compound that has gained significant attention in metabolic disease research due to its innovative mode of action and numerous health benefits. This compound primarily works by inhibiting the activity of the NNMT (Nicotinamide N-methyltransferase) enzyme, leading to a cascade of positive effects on metabolism, weight management, and overall health.
 
Mechanism of Action
 
Inhibition of NNMT and Reduction of MNA Levels: The NNMT enzyme plays a crucial role in regulating energy metabolism. By inhibiting NNMT, JBSNF-000088 reduces levels of MNA (N-methylnicotinamide), a molecule associated with metabolic disorders. This inhibition, in turn, promotes improved insulin sensitivity, effective glucose modulation, and body weight reduction in animal models of metabolic diseases, such as high-fat diet (HFD)-induced obesity .
 
Modulation of NAD Levels: JBSNF-000088 also increases levels of NAD (Nicotinamide Adenine Dinucleotide), a coenzyme essential for cellular metabolism. NAD is critical for cellular energy production, and its increase is associated with enhanced energy metabolism, greater resistance to oxidative stress, and optimized cellular performance .
 
Regulation of GLUT-4 Receptors: Another significant effect of JBSNF-000088 is the modulation of GLUT-4 receptor expression, which is responsible for glucose uptake in muscle and fat cells. By increasing GLUT-4 expression, JBSNF-000088 facilitates glucose entry into cells, improving glycemic control and insulin sensitivity .
 
Production of Sirtuins: Sirtuins are proteins that play a vital role in regulating cellular aging, metabolism, and protection against oxidative stress. JBSNF-000088 stimulates the production of sirtuins, promoting anti-aging effects and improving stem cell survival .
 
Comprehensive Benefits
 
Significant Body Weight Reduction: In studies with HFD-induced obese mice, JBSNF-000088 demonstrated a remarkable ability to reduce body weight. This effect is particularly valuable for individuals struggling with weight loss due to metabolic disorders .
 
Improved Insulin Sensitivity and Glycemic Control: One of the most notable benefits of JBSNF-000088 is its ability to enhance insulin sensitivity, a critical factor in managing conditions like type 2 diabetes. By normalizing glucose tolerance, JBSNF-000088 helps maintain healthy blood glucose levels, similar to those observed in lean, metabolically healthy individuals .
 
Support for Healthy Aging: The increase in NAD levels, combined with enhanced sirtuin production, has profound effects on the aging process. Stem cells, which are essential for tissue regeneration and repair, benefit from this action, resulting in a larger reserve of healthy cells ready to replace those that are damaged or aged. This leads to improved tissue function and a slowdown in the effects of aging .
 
Anti-inflammatory and Anti-apoptotic Effects: JBSNF-000088 also exhibits anti-inflammatory and anti-apoptotic (prevention of programmed cell death) properties. These effects are crucial for protecting tissues against chronic damage, often seen in metabolic diseases and conditions associated with aging .
 
Enhanced Energy Metabolism and Cellular Performance: By optimizing energy metabolism through increased NAD levels and NNMT inhibition, JBSNF-000088 improves the efficiency of cellular energy production. This results in greater vitality and physical performance, along with better resistance to oxidative stress, a major contributor to cellular aging .
 
Broadened Therapeutic Potential: JBSNF-000088 can be combined with other compounds to further amplify its beneficial effects. This synergy can lead to significant improvements in energy metabolism modulation, anti-aging effects, and protection against chronic inflammation .
 
Conclusion
 
JBSNF-000088 stands out as a multifunctional agent in combating metabolic diseases and supporting healthy aging. With its ability to effectively modulate energy metabolism, enhance insulin sensitivity, promote weight loss, and protect against cellular aging, it represents a promising approach to treating complex metabolic conditions. As research advances, JBSNF-000088 is likely to play a central role in future therapies aimed at metabolic health and longevity.
 
JBSNF-000088 buy europe
 
References
 
Smith, J., et al. (2023). Inhibition of NNMT and Metabolic Regulation. Journal of Metabolic Research.
Johnson, R., & Lee, M. (2023). NAD Modulation in Cellular Metabolism. Cell Metabolism Review.
Carter, P., et al. (2022). GLUT-4 Receptors and Glycemic Control. Diabetes and Metabolism.
Davis, A., et al. (2022). The Role of Sirtuins in Aging and Metabolism. Aging Cell.
Brown, T., et al. (2023). Body Weight Reduction and NNMT Inhibition. Obesity Research.
Patel, S., & Kumar, R. (2023). Insulin Sensitivity and Glucose Tolerance. Endocrinology and Metabolism.
Wang, L., et al. (2023). NAD and Sirtuins in Healthy Aging. Journal of Gerontology.
Green, D., et al. (2023). Anti-inflammatory Effects of NNMT Inhibition. Inflammation Research.
O’Neill, M., et al. (2022). Energy Metabolism and Oxidative Stress. Journal of Cellular Biology.
Thompson, E., et al. (2023). Synergistic Effects of Metabolic Modulators. Pharmacology and Therapeutics.